問題1
Before initiating thrombolytic therapy in a 58 year old patient who has just sustained an acute anterior MI, which of the following must be ascertained?
Before initiating thrombolytic therapy in a 58 year old patient who has just sustained an acute anterior MI, which of the following must be ascertained?
正確答案: D
問題2
A clinical trial is being designed to evaluate the efficacy of an intermediate-acting niacin preparation in a population with regard to amelioration of coronary artery disease risk.
Bioethical considerations would restrict recruitment of subjects with poorly controlled diabetes mellitus, recent gastroduodenal ulcer disease, or hyperuricemia. Which principle would consider these patients to be ineligible for enrollment?
A clinical trial is being designed to evaluate the efficacy of an intermediate-acting niacin preparation in a population with regard to amelioration of coronary artery disease risk.
Bioethical considerations would restrict recruitment of subjects with poorly controlled diabetes mellitus, recent gastroduodenal ulcer disease, or hyperuricemia. Which principle would consider these patients to be ineligible for enrollment?
正確答案: A
問題3
A 49-year-old man presents to his physician with a 3-day acute attack of gout in four joints of the right foot. The patient has a history of at least three previous gout attacks; in one, a joint aspirate was positive for urate crystals. His history also includes type 2 diabetes mellitus and two calcium oxalate kidney stones.
Laboratory values include creatinine 3.1 mg/dL, uric acid 11.7 mg/dL, and A1C 6.8%. The patient is allergic to aspirin. Vital signs are BP135/82mm Hg and HR 90 bpm and regular.
Current medications are glipizide 10 mg daily and enalapril 20 mg daily.
Which short-term regimen is most appropriate for treating this patient's gout?
A 49-year-old man presents to his physician with a 3-day acute attack of gout in four joints of the right foot. The patient has a history of at least three previous gout attacks; in one, a joint aspirate was positive for urate crystals. His history also includes type 2 diabetes mellitus and two calcium oxalate kidney stones.
Laboratory values include creatinine 3.1 mg/dL, uric acid 11.7 mg/dL, and A1C 6.8%. The patient is allergic to aspirin. Vital signs are BP135/82mm Hg and HR 90 bpm and regular.
Current medications are glipizide 10 mg daily and enalapril 20 mg daily.
Which short-term regimen is most appropriate for treating this patient's gout?
正確答案: D
問題4
Two antihypertensive regimens have been compared in 50 patients with mild hypertension.
Treatment A decreased mean diastolic blood pressure to 81 mm Hg, and Treatment B decreased it to 85mm Hg (p = 0.08, a priori critical a = 0.05). The most reasonable interpretation of these results is that the difference between treatments is:
Two antihypertensive regimens have been compared in 50 patients with mild hypertension.
Treatment A decreased mean diastolic blood pressure to 81 mm Hg, and Treatment B decreased it to 85mm Hg (p = 0.08, a priori critical a = 0.05). The most reasonable interpretation of these results is that the difference between treatments is:
正確答案: A
問題5
A pharmacotherapy specialist is conducting a pharmacokinetic study of a drug. The pharmacokinetic profile of this drug is best described by a one-compartment model with a mean elimination rate constant of 0.173/h. The standard curve for the assay to be used covers the range of 5-40mcg/mL. Samples are collected shortly after single intravenous bolus drug administration, and at 4 and 8 hours after dosing. Preliminary analysis shows that the 4-hour sample concentration is 25 mcg/mL. In this situation, which of the following statements is correct?
A pharmacotherapy specialist is conducting a pharmacokinetic study of a drug. The pharmacokinetic profile of this drug is best described by a one-compartment model with a mean elimination rate constant of 0.173/h. The standard curve for the assay to be used covers the range of 5-40mcg/mL. Samples are collected shortly after single intravenous bolus drug administration, and at 4 and 8 hours after dosing. Preliminary analysis shows that the 4-hour sample concentration is 25 mcg/mL. In this situation, which of the following statements is correct?
正確答案: D
問題6
In order to assess the effect of a potential metabolic enzyme inhibitor on the clearance of warfarin, the most appropriate study design would be which of the following?
In order to assess the effect of a potential metabolic enzyme inhibitor on the clearance of warfarin, the most appropriate study design would be which of the following?
正確答案: B
問題7
In a clinical trial, when would "intention to treat" analysis be most appropriate?
In a clinical trial, when would "intention to treat" analysis be most appropriate?
正確答案: B
問題8
The Joint Commission requires accredited organizations to encourage which groups to report concerns about safety?
The Joint Commission requires accredited organizations to encourage which groups to report concerns about safety?
正確答案: D
問題9
A 59-year-old patient with a diagnosis of deep vein thrombosis is anticoagulated with enoxaparin 1 mg/kg every 12 hours and warfarin 5 mg daily. On the third day of therapy, his INR
= 2.2. The patient is symptomatically improved. Which of the following is the most appropriate management of this patient?
A 59-year-old patient with a diagnosis of deep vein thrombosis is anticoagulated with enoxaparin 1 mg/kg every 12 hours and warfarin 5 mg daily. On the third day of therapy, his INR
= 2.2. The patient is symptomatically improved. Which of the following is the most appropriate management of this patient?
正確答案: D